When Lucky Luke's boisterous tomcat friend, Calamity Jane, is officially wanted (dead or alive) for crimes committed by Phil Fast Finger, assuming her loud red-hair posture, Lucky agrees to help her escape. So now the crook catcher is hunted down with her by every bounty hunter- and trace the real culprit, to which end he masquerades with her as the respectable couple Jones. Their stage coach gets trough an attack by Indians, the rivaling bounty hunters catch up, and so does Phil.